单位文秘网 2021-09-04 08:56:55 点击: 次
农业的科学发展,对培养多学科人才充实到传统药物研究具有引领作用。本草基因组学正促进前沿生命科学技术应用到中药领域,对中药现代化进程具有重大战略性科学意义。
[关键词]本草基因组学; 基因组学; 组学; 中药
[Abstract]Traditional Chinese medicine (TCM) has contributad greatly to improving human health However, the biological characteristics and molecular mechanisms of TCM in the treatment of human diseases remain largely unknown Genomics plays an important role in modern medicine and biology Here, we introduce genomics and other related omics to the study of herbs to propose a new discipline, Herbgenomics, that aims to uncover the genetic information and regulatory networks of herbs and to clarify their molecular mechanisms in the prevention and treatment of human diseases Herbgenomics includes herbal structural genomics, functional genomics, transcriptomics, proteomics, metabonomics, epigenomics and metagenomics Genomic information, together with transcriptomic, proteomic, and metabolomic data, can therefore be used to predict secondary metabolite biosynthetic pathways and their regulation, triggering a revolution in discoverybased research aimed at understanding the genetics and biology of herbs Herbgenomics provides an effective platform to support chemical and biological analyses of complex herbal products that may contain more than one active component Herbgenomics is now being applied to many areas of herb related biological research to help understand the quality of traditional medicines and for molecular herb identification through the establishment of an herbal gene bank Moreover, functional genomics can contribute to model herb research platforms, geoherbal research, genomicsassisted herb breeding, and herbal synthetic biology, all of which are important for securing the future of medicinal plants and their active compounds In addition, Herbgenomics will facilitate the elucidation of the targets and mechanism of herbs in disease treatment and provide support for personalized precise medicineHerbgenomics will accelerate the application of cuttingedge technologies in herbal research and provide an unprecedented opportunity to revolutionize the use and acceptance of traditional herbal medicines
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